Inclusion criteria:
•A male or female >= 18 years of age
•Written informed consent obtained from the subject.
•Free of obvious health problems as established by medical history and clinical examination before entering into the study.
•If the subject is female, she must be of non-childbearing potential, i.e. either surgically sterilized or one year post-menopausal; or, if of childbearing potential, she must be abstinent or have used adequate contraceptive precautions for 30 days prior to vaccination, have a negative pregnancy test and must agree to continue such precautions for two months after completion of the vaccination series.
Exclusion criteria:

•Use of any investigational or non-registered drug or vaccine other than the study vaccine during the study period.
•Chronic administration (defined as more than 14 days) of immunosuppressants or other immune-modifying drugs
within six months prior to the first vaccine dose. (For corticosteroids, this will mean prednisone, or equivalent,
greater than or equal to 0.5 mg/kg/day. Inhaled and topical steroids are allowed.)
•Planned administration/ administration of a vaccine not foreseen by the study protocol within 30 days of
the first dose of vaccine.
•Previous vaccination against hepatitis B
•History of hepatitis B infection
•Known exposure to hepatitis B within the previous 6 weeks
•Any confirmed or suspected immunosuppressive or immunodeficient condition, including human
immunodeficiency virus (HIV) infection.
•A family history of congenital or hereditary immunodeficiency.
•History of allergic disease or reactions likely to be exacerbated by any component of the vaccine(s).
•Acute disease at the time of enrolment. (Acute disease is defined as the presence of a
moderate or severe illness with or without fever. All vaccines can be administered to persons with a
minor illness such as diarrhoea, mild upper respiratory infection with or without low-grade febrile illness,
i.e. Oral temperature < 37.5°C (99.5°F) / Axillary temperature <37.5°C (99.5°F).
•Acute or chronic, clinically significant pulmonary, cardiovascular, hepatic or renal functional
abnormality, as determined by physical examination or laboratory screening tests.
•Administration of immunoglobulins and/or any blood products within the three months preceding the
first dose of study vaccine or planned administration during the study period.
Pregnant or lactating female.
•Female planning to become pregnant or planning to discontinue contraceptive precautions during the study period.

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• GSK Investigational Site
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