Inclusion criteria:
•Healthy as determined by a responsible physician
•Male, or only for the RDF cohort female of non-childbearing potential, between 18 and 65 years of age.
•Body weight greater than 50 kg (110 lbs) and BMI within the range 18.5-29.9 kg/m2 (inclusive).
•QTcB or QTcF < 450 msec
•Capable of giving written informed consent
Exclusion criteria:
•The subject has a positive pre-study drug/alcohol screen
•History of regular alcohol consumption within 6 months of the study defined as an average weekly intake of greater than 21 units
•Urinary cotinine levels indicative of active smoking or regular use of tobacco
•A positive pre-study Hepatitis B surface antigen or positive Hepatitis C antibody
•A positive test for HIV antibody
•The subject has participated in a clinical trial and has received an investigational product within 30 days, 5 half-lives of the investigational product
•Exposure to more than four new chemical entities within 12 months
•Use of prescription or non-prescription drugs, including vitamins, herbal and dietary supplements (including St John's Wort) within 7 days
•Consumption of red wine, seville oranges, grapefruit or grapefruit juice and/or pummelos, exotic citrus fruits, grapefruit hybrids or fruit juices within 7 days
•Subject is receiving hormone replacement therapy
•History of sensitivity to any of the study medications
•History of sensitivity to heparin or heparin-induced thrombocytopenia

• United Kingdom (click to view all sites in United Kingdom)
• GSK Investigational Site
  Harrow, Middlesex, HA1 3UJ; Recruiting;