Inclusion Criteria:

- Chronic dilated cardiomyopathy of ischemic or non-ischemic origin
- Clinically stable on optimal therapies for at least 3 months prior to screening/baseline visit.
- Left ventricular ejection fraction greater than or equal to 40% as assessed by any measurement in the previous 24 months.
- NYHA Class II/III heart failure for a minimum of 6 months prior to enrolment
- Male or female between 21 and 75 years of age inclusive, at the time of signing the informed consent. However the optimal age range for this study will be 40 to 65 years of age.
- A female subject is eligible to participate if she is of:
Non-childbearing potential defined as pre-menopausal females with a documented tubal ligation or hysterectomy; or postmenopausal defined as 12 months of spontaneous amenorrhea [in questionable cases a blood sample with simultaneous follicle stimulating hormone (FSH) > 40 MlU/ml and estradiol < 40 pg/ml (<140 pmol/L) is confirmatory].
Child-bearing potential and agrees to use one of the contraception methods listed in Section 8.1 for an appropriate period of time (as determined by the product label or investigator) prior to the start of dosing to sufficiently minimize the risk of pregnancy at that point. Female subjects must agree to use contraception until the follow-up visit ~28 days post-last dose.
- Capable of giving written informed consent, which includes compliance with the requirements and restrictions listed in the consent form.
- Confirmed QTcB or QTcF < 480 msec; or QTc < 500 msec in subjects with Bundle Branch Block.
- AST and ALT < 2xULN; alkaline phosphatase and bilirubin greater than or equal to 1.5xULN (isolated bilirubin >1.5xULN is acceptable if bilirubin is fractionated and direct bilirubin <35%).
- Subjects must be able to perform performance/exercise testing




Exclusion Criteria:

- A subject will not be eligible for inclusion in this study if any of the following criteria apply:
• Active ischemia manifest as a history of myocardial infarction or unstable angina in the past 12 months or a history of coronary revascularization (percutaneous coronary intervention and/or coronary artery bypass grafting) in the past 6 months.
-. High suspicion of active myocardial ischemia, in the opinion of the treating physician
- A positive pre-study Hepatitis B surface antigen or positive Hepatitis C antibody result within 3 months of screening
- History of drug/alcohol abuse.
- A positive test for HIV antibody.
- Calcitonin > 100 pg./mL
- Triglycerides > 850 mg/dL
- History of significant gastrointestinal surgery, including gastric bypass and banding, antrectomy, Roux-en-Y bypass, gastric vagotomy, small bowel resection, or surgeries thought to significantly affect upper gastrointestinal function.
- History of regular alcohol consumption within 6 months of the study defined as:
For UK: an average weekly intake of >21 units for males or >14 units for females. One unit is equivalent to 8 g of alcohol: a half-pint (~240 ml) of beer, 1 glass (125 ml) of wine or 1 (25 ml) measure of spirits.
For US: an average weekly intake of >14 drinks for males or >7 drinks for females. One drink is equivalent to 12 g of alcohol: 12 ounces (360 ml) of beer, 5 ounces (150 ml) of wine or 1.5 ounces (45 ml) of 80 proof distilled spirits.
- The subject has participated in a clinical trial and has received an investigational product within the following time period prior to the first dosing day in the current study: 30 days, 5 half-lives or twice the duration of the biological effect of the investigational product (whichever is longer).
- Exposure to more than four new chemical entities within 12 months prior to the first dosing day.
- Known allergy or history of sensitivity to albiglutide, any other GLP-1 analogue, , or Baker’s yeast.
- Where participation in the study would result in donation of blood or blood products in excess of 500 mL within a 56 day period.
- Pregnant females as determined by positive serum or urine hCG test at screening or prior to dosing.
- Lactating females.
- Unwillingness or inability to follow the procedures outlined in the protocol (e.g.. related to psychiatric disorder)
- Subject is mentally or legally incapacitated.
- Known diagnosis of diabetes mellitus, fasting glucose >140mg/dL, or HbA1c > 7%.
- Uncorrected thyroid disease manifest as an abnormal thyroid-stimulating hormone (TSH) (outside reference range at screening).
- Other medical problems with life expectancy less than 1yr.
- Other causes of cardiomyopathy or left ventricular dysfunction including:
Uncorrected primary obstructive or regurgitant valvular disease
Restrictive cardiomyopathy due to amyloidosis, hemochromatosis, sarcoidosis or other cause
Cardiac hypertrophy with wall thickness >1.5cm
Alcohol-induced cardiomyopathy
Women with heart failure during the 12 months following childbirth.
Complex congenital heart disease
Anthracycline induced cardiomyopathy
- Subjects with genetic disorders of skeletal muscle (e.g. Duchenne muscular dystrophy)
- Clinically significant pericardial disease.
- Listed as a status 1A or 1B on heart transplant waiting list.
- History of deep vein thrombosis or a known coagulation disorder
- History of pancreatitis
- History of or family history of medullary thyroid carcinoma
- History of or family history of multiple endocrine neoplasia type 2
- History of renal dysfunction with estimated GFR < 40 ml/min at screening
- Resting systolic blood pressure < 85 mmHg or >170 mmHg; or diastolic blood pressure >110 mgHg at screening.
- Inability of the patient to lie flat for a combined total of up to 4 hours to complete imaging assessments.
- No subjects will be enrolled at the single site performing the CMR sub-study who have contraindications to MRI scanning including, but not limited to:
Intracranial aneurysm clips with an appropriate operative conformation
History of intra
• orbital metal fragments
Pacemakers or non-MR compatible heart valves
Inner ear implants
History of claustrophobia deemed significant by the investigator

• United Kingdom (click to view all sites in United Kingdom)
• GSK Investigational Site
  London, W12 0HS; COMPLETED;
  Contact: Stuart Cook, Principal Investigator, .
• GSK Investigational Site
  Oxford, OX3 9DU; COMPLETED;
  Contact: Stefan Neubauer, Principal Investigator, .
• GSK Investigational Site
  Cambridge, Cambridgeshire, CB2 0QQ; COMPLETED;
  
• United States (click to view all sites in United States)
• Georgia (click to view)
• GSK Investigational Site
  Savannah, Georgia, 31405; COMPLETED;
  Contact: William Wallace, Principal Investigator, .
• Louisiana (click to view)
• GSK Investigational Site
  Metairie, Louisiana, 70006; COMPLETED;
  Contact: Robert J Jeanfreau, Principal Investigator, .
• Maine (click to view)
• GSK Investigational Site
  Auburn, Maine, 04210; NOT YET RECRUITING;
  Contact: Robert J Weiss, Principal Investigator, .
• Maryland (click to view)
• GSK Investigational Site
  Baltimore, Maryland, 21287; COMPLETED;
  Contact: Stuart Russell, Principal Investigator, .
• Michigan (click to view)
• GSK Investigational Site
  Detroit, Michigan, 48202; COMPLETED;
  Contact: Karthikeyan Ananthasubramaniam, Principal Investigator, .
• Minnesota (click to view)
• GSK Investigational Site
  Minneapolis, Minnesota, 55407; COMPLETED;
  Contact: Barry M Cabuay, Principal Investigator, .
• Missouri (click to view)
• GSK Investigational Site
  St Louis, Missouri, 63110; COMPLETED;
  Contact: Gregory Ewald, Principal Investigator, .
• New Jersey (click to view)
• GSK Investigational Site
  Newark, New Jersey, 7103; COMPLETED;
  Contact: James Maher, Principal Investigator, .
• New York (click to view)
• GSK Investigational Site
  Stony Brook, New York, 11794; COMPLETED;
  Contact: Hal A Skopicki, Principal Investigator, .
• Ohio (click to view)
• GSK Investigational Site
  Columbus, Ohio, 43210; COMPLETED;
  Contact: Garrie Haas, Principal Investigator, .
• Pennsylvania (click to view)
• GSK Investigational Site
  Philadelphia, Pennsylvania, 19104; COMPLETED;
  Contact: Thomas Cappola, Principal Investigator, .