Inclusion Criteria:

• Capable of understanding and willing to provide signed and dated written voluntary informed consent (and any local or national authorization requirements) before any protocol-specific procedures are performed.
-Male or female ages 12 to 35 years, inclusive at time of consent.
-ISGA score of 3 or 4 at Baseline.
-Lesion counts meeting all of the following criteria: A: A minimum of 25 but not more than 50 facial inflammatory lesions (papules and pustules), excluding nasal lesions. B: A minimum of 20 but not more than 100 facial non-inflammatory lesions (open and closed comedones), excluding nasal lesions. C: No more than 3 facial nodular lesions (<5mm), with no cystic lesions.
-Ability and willingness to follow all study procedures, attend all scheduled visits, and successfully complete the study.
-Negative urine pregnancy test for females of childbearing potential.
-Sexually active females of childbearing potential participating in the study must agree to use a medically acceptable method of contraception while receiving protocol-assigned product.


Exclusion Criteria:

-Female who is pregnant, trying to become pregnant, or breast feeding.
-History of lupus, dermatomyositis, rosacea, seborrheic dermatitis, beard folliculitis, polycystic ovary syndrome, hirsutism, or perioral dermatitis. (Subjects with Seborrheic dermatitis may be enrolled if the condition has been inactive for at least 1 year and/or it does not affect the face.)
-Use of topical antibiotics on the face within the past 2 weeks or of systemic antibiotics for acne treatment within the past 4 weeks.
-Concurrent use of medications known to be photosensitizers (eg, thiazides, tetracyclines, fluoroquinolones, phenothiazines, and sulfonamides) because of the possibility of augmented photosensitivity.
-Use of topical corticosteroids on the face within the past 2 weeks or systemic corticosteroids within the past 4 weeks. Use of inhaled, intra-articular, or intra-lesional steroids other than for facial acne is acceptable.
-Use of systemic retinoids (eg, isotretinoin) within the past 6 months.
-Treatment with estrogens, including oral, implanted, injected, and topical contraceptives, androgens, or anti-androgenic agents for 12 weeks or fewer immediately prior to study enrollment. Subjects that have been treated with estrogens, as described above, androgens, or anti-androgenic agents for more than 12 consecutive weeks prior to study enrollment are allowed to enroll as long as they do not expect to change the dose or drug, or to discontinue use during the study and it has not been indicated for the treatment of acne vulgaris.
-Male with facial hair that could interfere with study assessments.
-Use of topical anti-acne medications (eg, BPO, retinoids, azelaic acid, resorcinol, sulfur and derivatives, SA, alpha or beta hydroxy acids, antioxidants, anti-wrinkle, antimicrobials, glycolic acid, abradants) within the past 2 weeks. Use of superficial facial procedures, and natural/herbal products within the past 4 weeks.
-Concomitant use of medications that are reported to exacerbate acne as these may impact efficacy assessments.
-Facial procedure (eg, blue light, chemical or laser peel, microdermabrasion) performed by aesthetician, beautician, physician, nurse, or other practitioner within the past 8 weeks.
-facial skin cancer diagnosis in preceding 12 months.
-Require or desire excessive or prolonged exposure to ultraviolet light (eg, sunlight or tanning beds) during the study.
-Dermatological disorder that in the opinion of the investigator may interfere with the accurate evaluation of the subject's facial appearance.
-Any major illness within 4 weeks before study enrollment.
-Previous use of the study products.
-Use of any investigational drug or procedure within the past 4 weeks or currently participating in another clinical study.
-Known hypersensitivity or previous allergic reaction to any of the active components of the study product.
-Any other condition which, in the judgement of the investigator, would put the subject at unacceptable risk for participation in the study.
-Current drug or alcohol abuse. (Drug screening is not required.)
-Considered unable or unlikely to attend the necessary visits.
-Employee of the investigator, clinical research organization, Stiefel, a GSK company, or GlaxoSmithKline (GSK) who is involved in the study, or an immediate family member (eg, partner, offspring, parents, siblings or sibling's offspring) of an employee who is involved in the study.

•

• United States (click to view all sites in United States)
• California (click to view)
• GSK Investigational Site
  Fremont, California, 94538; Completed;
  Contact: Sunil S Dhawan, Principal Investigator, .
• Kentucky (click to view)
• GSK Investigational Site
  Louisville, Kentucky, 40217; Completed;
  Contact: Leon Kircik, Principal Investigator, .
• Maryland (click to view)
• GSK Investigational Site
  Rockville, Maryland, 20850; Completed;
  Contact: Lawrence J Green, Principal Investigator, .
• New Jersey (click to view)
• GSK Investigational Site
  Montclair, New Jersey, 07042; Completed;
  Contact: Jeanine B Downie, Principal Investigator, .
• GSK Investigational Site
  Belleville, New Jersey, 07109; Completed;
  Contact: Joseph S Eastern, Principal Investigator, .
• New York (click to view)
• GSK Investigational Site
  Stony Brook, New York, 11790; Completed;
  Contact: Elyse S Rafal, Principal Investigator, .
• North Carolina (click to view)
• GSK Investigational Site
  High Point, North Carolina, 27262; Completed;
  Contact: Zoe D Draelos, Principal Investigator, .
• Tennessee (click to view)
• GSK Investigational Site
  Knoxville, Tennessee, 37922; Completed;
  Contact: Kimberly Grande, Principal Investigator, .
• Texas (click to view)
• GSK Investigational Site
  Austin, Texas, 78759; Completed;
  Contact: Michael Jarratt, Principal Investigator, .