Inclusion Criteria:

•Between 18 and 40 years old.
•Written informed consent will have been obtained from the subjects.
•Good physical condition as established by physical examination and history taking at the time of entry.
•Female participants will avoid becoming pregnant during the study period and they will have been on a contraceptive program for at least 2 months before entry



Exclusion Criteria:

•Pregnancy or lactation.
•Positive titres for anti hepatitis B antibodies
•Any vaccination against hepatitis B in the past.
•Any previous administration of MPL.
•Elevated serum liver enzymes.
•History of significant and persisting hematologic, hepatic, renal, cardiac or respiratory disease.
•Axillary temperature > 37.5°C at the time of injection.
•Any acute disease at the moment of entry.
•Chronic alcohol consumption.
•Any treatment with immunosuppressive or immunostimulant therapy.
•Any chronic drug treatment, which in the investigator's opinion, precludes inclusion into the study.
•History of allergic disease likely to be stimulated by any component of the vaccine.
•Simultaneous administration of any other vaccine(s).
•Administration of any immunoglobulin during the study period.
•Simultaneous participation in any other clinical trial