Inclusion Criteria:

•Age: older than 18 years of age.
•Documented non-responders 2 to 5 months after having received 4 doses of a hepatitis B vaccine
•Good physical condition as established by clinical examination and history taking at the time of entry.
•Female participants who are at risk to become pregnant will be on a contraceptive programme if necessary during the study period.
•Written informed consent obtained from the subjects



Exclusion Criteria:

•Positive at screening for anti-HBV antibodies
•Elevated serum liver enzymes.
•History of significant and persisting hematologic, hepatic, renal, cardiac or respiratory disease.
•Any acute disease at the moment of entry.
•Chronic alcohol consumption.
•Hepatomegaly, right upper quadrant abdominal pain or tenderness.
•Any chronic drug treatment, including any treatment with immunosuppressive drugs, which in the investigator's opinion, precludes inclusion into the study.
•History of allergic disease likely to be stimulated by any component of the vaccine.
•Simultaneous participation in any other clinical trial.
•Previous vaccination with an MPL containing vaccine.
•Administration of immunoglobulins 6 months before and during the whole study period
•Vaccination one month before and one month after each dose of the study vaccine