Inclusion:
•Are aged between 18-70 years, inclusive.
•If Female, you must be incapable of becoming pregnant.
•Show FEV1 of more than 70% of the predicted normal at screening.
•Are able to correctly use a DISKUS at the screening visit.
•Have Body Mass Index within the range of 19-33 kg/m2 inclusive.
•Do not show a positive pre-study urine drug screen.
•Do not show a positive pre-study blood alcohol test.
•Demonstrate a clinically normal 12-lead ECG at screening.
•Do not show a positive blood test for HIV.

If you are a Healthy Volunteer you must also:
•Have no significant abnormality on clinical examination.
•Have Liver Function Tests within the reference range at screening.

If you are a Patient Volunteer you must:
•Have moderate hepatic impairment
•Have no significant abnormality on clinical examination apart from hepatic impairment.

Exclusion:
•Suffered an upper respiratory infection in the 4 weeks before the screening visit.
•Suffered a lower respiratory infection in the 6 weeks before the screening visit.
•Taken oral corticosteroids in the 8 weeks before the screening visit.
•Taken inhaled, intranasal or topical steroids in the 4 weeks before the screening visit.
•A prolonged heartbeat (QTc interval >470msec).
•High blood pressure (systolic >160mmHg or diastolic >90mmHg) or as defined by the Investigator.
•Known sensitivity to corticosteroids.
•A history of lactose intolerance.
•A history of severe milk protein allergy.
•Donated blood in the last 3 months, or more than 1500mL (1000mL if female) in the last 12 months (including the amount taken for this study).
•Participated in a clinical trial within the last 3 months where you are/were exposed to a drug or device.