Home > Result Summaries: Compounds > atovaquone/proguanil Result Summaries: atovaquone/proguanil GSKStudy ID Phase Title Summary (Download) 115-003 Phase 3 A Multicentre Pilot Study in the United Kingdom to Determine Whether 566C80 Exhibits Antimalarial Activity in Patients with P. Falciparum Malaria. (2 citation(s)) 115-005 Phase 2 An Open Study to Determine Whether 566C80 (Atovaquone) Exhibits Antimalarial Activity in Thai Patients with P. falciparum Malaria (3 citation(s)) 115-012 Phase 2 An open study to determine whether 566C80 (atovaquone) exhibits antimalarial activity in Zambian patients with P. falciparum malaria (1 citation(s)) 115-120 Phase 3 A Comparative Trial of a Combination of Atovaquone and Proguanil versus Chloroquine or Fansidar in the Treatment of Acute P. falciparum Malaria in Adults in Zambia (1 citation(s)) 115-122 Phase 3 Comparative Clinical Trial of a Combination of Atovaquone and Proguanil with Mefloquine in the Treatment of Acute P. falciparum Malaria in Adults in Thailand (1 citation(s)) 115-123 Phase 3 Uncontrolled Clinical Trial of a Combination of Atovaquone and Proguanil in the Treatment of Acute P. falciparum Malaria in Children in Thailand (1 citation(s)) 115-127 Phase 3 Comparative Clinical Trial of a Combination of Atovaquone and Proguanil Versus a Combination of Quinine and Tetracycline in the Treatment of Acute P. falciparum Malaria in Adults in Brazil (1 citation(s)) 115-130 Phase 3 Comparative clinical trial of a combination of atovaquone and proguanil versus halofantrine in the treatment of acute P. falciparum malaria in non-immune adults in Europe (1 citation(s)) 115-131 Phase 3 Comparative clinical trial of a combination of atovaquone and proguanil versus halofantrine in the treatment of acute P. falciparum malaria in children in Kenya (1 citation(s)) 115-132-V Phase 1 A Study to Compare the Bioavailability of Atovaquone and Proguanil from Combination Tablets and from Atovaquone Tablets and Proguanil Tablets given Concomitantly (0 citation(s)) 115-133 Phase 1 Report of a Randomised Study to Evaluate a Potential Pharmacokinetic Interaction between Proguanil and Atovaquone in Healthy Adult Volunteers (1 citation(s)) 115-134 Phase 3 Comparative clinical trial of a combination of atovaquone and proguanil versus amodiaquine in the treatment of acute P. falciparum malaria in adults in Gabon (2 citation(s)) 115-135 Phase 3 Final Study Report for Protocol 115-135: Comparative Clinical Trial of a Combination of Atovaquone and Proguanil versus Chloroquine in the Treatment of Acute P. falciparum Malaria in Adults and Children in the Philippines (1 citation(s)) 115-136 Phase 3 Comparative Clinical Trial of a Fixed Formulation of Atovaquone and Proguanil tablets (MALARONE) Versus Chloroquine in the Treatment of Acute P. falciparum Malaria in Adults or Children in Peru (2 citation(s)) 116441 phase 1 Single Oral Dose Study of Atovaquone/Proguanil Hydrochloride Combination Tablets and Atovaquone Suspension. - A Single Oral Dose Study to Investigate Pharmacokinetics of Atovaquone and Proguanil from Combination Tablets and Atovaquone from Atovaquone Suspension in Japanese Healthy Males. - (0 citation(s)) EPI40105 Phase 4 A post-marketing surveillance study of subject-reported adverse events rates for Malarone (atovaquone and proguanil), mefloquine and chloroquine/proguanil, when used for prophylaxis for travel up to 28 days maximum (1 citation(s)) MAL10907 Phase 1 An open label, parallel group, single oral dose study to investigate the pharmacokinetics of MALARONE in healthy elderly subjects compared to healthy young subjects (0 citation(s)) MAL10908 Phase 1 An open label, parallel group, single oral dose study to investigate the pharmacokinetics of MALARONE in subjects with severe renal impairment compared to healthy subjects. (0 citation(s)) MAL10909 Phase 1 An Open Label, Parallel Group, Single Oral Dose Study to Investigate the Pharmacokinetics of MALARONE in Subjects with Mild to Moderate Hepatic Impairment Compared to Healthy Subjects (0 citation(s)) MAL30010 Phase 3 An International, Randomized, Double-Blind Study to Compare the Safety and Efficacy of MALARONE (Atovaquone and Proguanil Hydrochloride) Versus Mefloquine for Chemoprophylaxis Against Malaria in Non-Immune Travelers (1 citation(s)) MAL30011 Phase 3 An International, Randomized, Double-Blind Study to Compare the Safety and Efficacy of MALARONE (Atovaquone and Proguanil Hydrochloride) Versus Chloroquine and Proguanil Hydrochloride for Chemoprophylaxis Against Malaria in Non-Immune Travelers (3 citation(s)) MAL30012 Phase 3 An International, Randomized, Open-Label Study to Compare the Safety and Efficacy of MALARONE (Atovaquone and Proguanil Hydrochloride) Versus Chloroquine and Proguanil Hydrochloride for Chemoprophylaxis Against Malaria in Non-Immune Pediatric Travelers (3 citation(s)) MAL30013 Phase 3 An Open-Label Comparative Study to Determine the Safety and Efficacy of MALARONE (Atovaquone and Proguanil Hydrochloride) Versus Amodiaquine in the Treatment of Acute Plasmodium falciparum Malaria in Children Weighing 5 and <11kg in Gabon (3 citation(s)) MAL30014 Phase 3 A Randomized, Double-Blind, Placebo-Controlled Study of MALARONE (Atovaquone and Proguanil Hydrochloride) as a Causal Prophylactic Agent Against Mosquito-Transmitted P. falciparum Malaria in Healthy Non-Immune Volunteers (1 citation(s)) MAL30015 Phase 4 A Randomized, Double-Blind, Placebo-Controlled, Parallel Group Study to Evaluate the Safety and Efficacy of MALARONE (Atovaquone and Proguanil Hydrochloride) for the Prevention of Plasmodium falciparum Malaria in Gabonese Children, and the Effect on Antibody Response to Typhoid and Cholera Vacci ... (2 citation(s)) MAL40009 Phase 4 An Open-Label, Uncontrolled Study to Evaluate the Safety and Efficacy of MALARONE (Atovaquone and Proguanil Hydrochloride) for Treatment of Acute Plasmodium falciparum Malaria in Thailand Using Tablets Manufactured in Canada (0 citation(s)) MAL40010 Phase 4 A Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety and Efficacy of Malarone (atovaquone and proguanil hydrochloride) for Malaria Prophylaxis in Non-Immune Colombian Soldiers. (1 citation(s)) MALA4001 Phase 3 An Open Label Study to Determine the Safety and Efficacy of a Sequential Treatment Regimen of MALARONE (atovaquone/proguanil) Followed by Primaquine in the Treatment of Acute Plasmodium vivax Malaria in Adults (0 citation(s)) MALA4002 Phase 3 An Open-Label Study to Determine the Efficacy and Safety of a Sequential Treatment Regimen of MALARONE (Atovaquone and Proguanil Hydrochloride) Followed by Primaquine for the Treatment of Acute Plasmodium Vivax Malaria in Thailand. (1 citation(s)) MALB2001 Phase 2 A Randomised, Double-Blind, Placebo-Controlled, Parallel Group Study to Determine the Chemosuppressive Activity of a Fixed Dose Combination of Atovaquone/Proguanil (MALARONE) in Volunteers at Risk of Developing P. falciparum Malaria in Kenya (1 citation(s)) MALB2002 Phase 2 Prophylactic Antimalarial Activity of Atovaquone in Volunteers Challenged with Plasmodium falciparum (1 citation(s)) MALB3001 Phase 3 A Randomised, Double–Blind, Placebo–Controlled, Parallel Group Study to Evaluate the Suppressive Prophylactic Activity of MALARONE (atovaquone/proguanil) in Volunteers at Risk of Developing P. falciparum Malaria in Zambia (1 citation(s)) MALB3002 Phase 3 An Open-Label Study to Evaluate the Safety and Efficacy of MALARONE (atovaquone/proguanil) as a Suppressive Prophylactic Agent Against Plasmodium falciparum Malaria in South Africa (1 citation(s)) MALB3003 Phase 3 A Randomised, Double–Blind, Placebo–Controlled, Parallel Group Study to Evaluate the Suppressive Prophylactic Activity of MALARONE (atovaquone/proguanil) in Children at Risk of Developing Plasmodium falciparum Infection (1 citation(s)) MALB3005 Phase 3 A Randomized, Double-Blind, Placebo-Controlled Trial of Malarone (Atovaquone 250mg and Proguanil Hydrochloride 100mg) Daily for Prophylaxis Against Plasmodium vivax and Plasmodium falciparum Infection in Javanese Transmigrants to Irian Jaya, Indonesia. (1 citation(s)) MALB3006 Phase 3 An Open-Label Comparative Study to Determine the Safety and Efficacy of MALARONE (Atovaquone and Proguanil Hydrochloride) Versus Chloroquine in the Treatment of Acute Plasmodium falciparum Malaria in Children 5 and <11 kg in Weight in Nigeria (0 citation(s))
