Home > Result Summaries: Compounds > trametinib Result Summaries: trametinib GSKStudy ID Phase Title Summary (Download) 112110 phase 1 An Open-Label, Dose-Escalation, Phase IB II Study to Investigate the Safety, Pharmacokinetics, Pharmacodynamics and Clinical Activity of the MEK Inhibitor GSK1120212 in Combination with Oral Everolimus in Subjects with Solid Tumors (0 citation(s)) 112111 phase 1 A Phase IB Combination Study of MEK inhibitor GSK1120212 with Gemcitabine in Subjects with Solid Tumors (0 citation(s)) 113487 phase 2 A Randomized, Double-Blind Placebo-Controlled Phase II Study of the MEK inhibitor GSK1120212 plus Gemcitabine vs Placebo plus Gemcitabine in Subjects with Metastatic Pancreatic Cancer (0 citation(s)) 113583 phase 2 An Open-Label, Multi-Center Study to Investigate the Objective Response Rate, Safety, and Pharmacokinetics of GSK1120212, a MEK Inhibitor, in BRAF Mutation-positive Melanoma Subjects Previously Treated with or without a BRAF Inhibitor (1 citation(s)) 113708 phase 1 An Open-label mass balance study to investigate the Absorption, Distribution, Metabolism and Elimination of a Single Oral Dose of MEK inhibitor [14C]GSK1120212 in Male Subjects with Solid Tumors (11 citation(s)) 113709 phase 1 An Open-Label, Two-Period, Randomized, Crossover Study to Evaluate the Effect of Food on the Single Dose Pharmacokinetics of the MEK Inhibitor, GSK1120212, in Subjects with Solid Tumors (0 citation(s)) 114267 phase 3 A Phase III randomized, open-label study comparing GSK1120212 to chemotherapy in subjects with advanced or metastatic BRAF V600E/K mutation-positive melanoma (2 citation(s)) 115064 phase 1 Determination of the Absolute Bioavailability of GSK1120212 Following a Single Oral Dose Co-Administered with an Intravenous Radiolabelled Microdose of GSK1120212 in Subjects with solid Tumors (0 citation(s)) MEK111054 phase 1 An Open-Label, Multiple-Dose, Dose-Escalation Study to Investigate the Safety, Pharmacokinetics, and Pharmacodynamics of the MEK Inhibitor GSK1120212 in Subjects with Solid Tumors or Lymphoma (2 citation(s))
